Normal plasma vWF antigen levels are 50% to 150%. ALF patients were advised liver transplantation, those not opting for transplantation underwent plasma exchange and NAC infusion ALI patients received NAC☟FP infusions (plasma exchange, if worsening) UAH patients had oral NAC. Method In this retrospective analysis of prospectively collected data, patients were classified to have uncomplicated acute hepatitis/UAH (deranged LFT, INR ≤1.5), acute liver injury/ALI (deranged LFT, INR >1.5) and acute liver failure/ALF (ALI, hepatic encephalopathy). We report outcome of vWF lowering therapies: N–acetyl cysteine (NAC), fresh frozen plasma (FFP) infusions and plasma exchange in these patients. Introduction High vWF levels may predispose to platelet microthrombi and multi-organ failure in phosphorus poisoning induced hepatotoxicity. Outcome of management protocol to reduce von Willebrand factor (vWF) in acute hepatic dysfunction: Hepatotoxicity due to yellow phosphorus (rat killer) poisoning as a prototypeĭebasis Sardar, Nitty Mathews, Joy Mammen, S C Nair, Shibu Jacob, Mousumi Sen, Vijayalekshmi, K A Balasubramanian, K Subramani, Lovely Thomas, K P P Abhilash, Shankar Jhanwar, Ashish Goel, Uday Zachariah, Elwyn Eias, C E EapenĬorrespondence- C E and Hepatology, Christian Medical College, Vellore 632 004, India
